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KMID : 1216720100020010039
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Korean Journal of Gynecologic Endocrinology
2010 Volume.2 No. 1 p.39 ~ p.44
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Changes in Blood Coagulation Factors of an Oral Continuous Combined Regimens of Estradiol 1 mg and Drospirenone 2 mg in Korean Postmenopausal Women: A Double-blind, Randomized, Placebo-controlled, Multicenter Study
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Chun Sung-Wook
Kang Byung-Moon
Kim Jung-Gu
Park Hyoung-Moo
Yoon Byung-Koo
Lee Byung-Seok
Choi Hoon
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Abstract
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Objectives: The aim of this study was to evaluate the effect of an estradiol 1 mg/drospirenone 2 mg regimen on changes in blood coagulation factors in Korean postmenopausal women. Methods: This was a multicenter, double-blind, randomized, placebo-controlled study over four 28-day treatment cycles. The changes in weight, blood pressure, pulse rate and prothrombin time (PT)/activated partial thromboplastin time (aPTT) were evaluated at outpatient clinics’ follow-up. A total of 158 subjects were screened and 90 women were randomized into two treatment groups. Results: The baseline results of PT/aPTT in both group were similar (study group: 13.18±0.853 and 33.08±4.794 (sec); control group 13.25±0.568 and 34.87±5.346 (sec)). The changes in PT from baseline were 0.08±0.846 (sec) in study group and -0.02±0.390 (sec) in placebo group at follow-up, with no significant differences. The changes in aPTT from baseline to the follow-up did not showed any differences between the study and control groups (-2.15±2.214 vs -1.75±3.464). Conclusion: Postmenopausal women treated with an estradiol 1 mg/drospirenone 2 mg regimen showed no effect on the changes of blood coagulation factors.
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KEYWORD
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Estradiol/drospirenone, PT, aPTT
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